When it comes to India, there is a tremendous demand for capsules. In the pharmaceutical sector, low-cost capsule manufacturers in India bring opportunities for investors, and results increase in the capsule market. A solid dosage form comprises capsules in which the drug is not enclosed in a soft or hard soluble container. The significant factors increasing the pharmaceutical capsules market are:
- Capsule delivery technologies advancement.
- The growth of the pharmaceutical market with increasing clinical trials & R&D activities.
- Capsule formulations are growing in adoption among the growing senior population.
Raw materials required
- Preservatives
- Opacifying agents
- Colorants
- Plasticizer
- Gelatin
Manufacturing steps for the medicines
- Gelatin solution preparation- A concentrated gelatin solution is prepared by dissolving gelatin mainly in demineralized water. This solution is highly viscous and leads to bubbles due to air entrapment. For removing the air bubbles, the application of vacuum is made to the solution, and this process duration varies with batch size.
- Gelatin solution dip coating onto metal pins- The manufacturing of Capsule shells is under strict climate conditions by standardized steel pins dipping pairs. They are arranged on metal bars as rows into an aqueous gelatin solution maintained in a jacketed heating pan.
- Dip coated pin’s rotation- Following gelatin solution’s absorption onto the pin’s surface. The bar comprising the pins is removed and several times rotated to distribute the solution evenly around the pins. Gelatin’s correct distribution is critical to precise and uniform capsule strength and wall thickness.
- Gelatin coated pin’s drying- Set the gelatin on the mold by a blast of cool air after the even distribution of gelatin. The gelatin is finally dried, and then the pins are passed through many drying stages for achieving the moisture content target.
- Trimming and stripping- The dried gelatin is trimmed to the proper length after the capsule is stripped off the mold.
- Trimmed capsule shell joining- Once trimmed, the body and cap or simply two halves are linked to the pre-closed position through a pre-lock mechanism.
- Printing- The capsule shells after formation can be printed for identification improvement. It can be achieved by using one or two colors, comprising information like the manufacturer’s logo or name, product code number or name, and dosage details. It reduces the product confusion by numerous users and handlers of the product comprising nurses, manufacturers, patients, pharmacists, etc.
Wrapping up
It can be concluded that capsules are supplied and fabricated empty to the pharmaceutical industry through shell suppliers and later filled in distinctive operation. The capsule manufacturers in India use the process of step by step and capsule supplying that needs strict quality control. Quality-checked medicines are essential for people’s health, and the top pharma companies are dedicated to that. Capsule manufacturers ensure that medicines go through multiple stages of verifications and quality checks to provide the safest and most effective medicines for most health problems and across varied age ranges.
